a ISSN 1976-1902

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL385

b Item number .N48 2012

a Personal name Harman, Ferhat.

h Medium Electronic Document

a Title Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.

c Statement of responsibility, etc Ferhat Harman, Askin Esen Hasturk, Mehmet Yaman, Turkan Arca, Kamer Kilinc, Mustafa Fevzi Sargon, Erkan Kaptanoglu.

c Date of publication, distribution, etc 2012.

b Name of publisher, distributor, etc SpringerLink,

a Summary, etc PURPOSE: The aim of this study was to investigate the neuroprotective effects of propofol, thiopental, etomidate, and midazolam as anesthetic drugs in fetal rat brain in the ischemia-reperfusion (IR) model. METHODS: Pregnant rats of day 19 were randomly allocated into eight groups. Fetal brain ischemia was induced by clamping the utero-ovarian artery bilaterally for 30 min and reperfusion was achieved by removing the clamps for 60 min. In the control group, fetal rat brains were obtained immediately after laparotomy. In the sham group, fetal rat brains were obtained 90 min after laparotomy. In the IR group, IR procedure was performed. No treatment was given in the IR group. One milliliter intralipid solution, 40 mg/kg propofol, 3 mg/kg thiopental, 0.1 mg/kg etomidate, and 3 mg/kg midazolam was administered intraperitoneally in the vehicle group, propofol group, thiopental group, etomidate group, and midazolam group, respectively, 20 min before IR procedure. At the end of the reperfusion period, the whole brains of the fetal rats were removed for evaluation of thiobarbituric acid reactive substances and for examination by electron microscopy. RESULTS: According to lipid peroxidation data, all the anesthetic drugs provide neuroprotection; however, ultrastructural findings and mitochondrial scoring confirms that only propofol and midazolam provides a strong neuroprotective effect. CONCLUSIONS: Propofol and midazolam may be used to protect fetal brain in case of acute fetal distress and hypoxic injury as a first choice anesthetic drug in cesarean delivery.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Neuroprotection

a Topical term or geographic name as entry element Propofol

a Topical term or geographic name as entry element Thiopental

a Topical term or geographic name as entry element Midazolam

g Relationship information Jul 2012, 28(7):1055-62

t Title Children Nervous Systems

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s00381-012-1782-0