a Record control number 000341414400004

a ISSN 0041-4301

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WS 18.2

b Item number .R45 2013

a Personal name Turkmen, Mehmet.

h Medium Electronic Document

a Title The relationship between renal P-glycoprotein expression and response to steroid therapy in childhood nephrotic syndrome .

c Statement of responsibility, etc Mehmet Türkmen, Meral Torun-Bayram, Alper Soylu, Erdener Özer, Sülen Sarıoğlu, Salih Kavukçu.

b Name of publisher, distributor, etc Turkısh J Pedıatrıcs,

c Date of publication, distribution, etc 2013.

a Place of publication, distribution, etc Ankara :

a Summary, etc In this study, we aimed to investigate the relationship between renal P-glycoprotein (rP-gp) expression and response to corticosteroid therapy in childhood nephrotic syndrome (NS). Expression of rP-gp was evaluated prior to non-steroid immunosuppressive therapy in children with NS (Group 1), prior to any treatment in children with immunoglobulin (Ig) A nephropathy (Group 2), and during renal donation in healthy adults (Group 3); mesangial proliferation was evaluated in Groups 1 and 2. Total dosage of steroid was calculated in Group 1. The ratio of rP-gp (+) glomeruli was higher in Group 1 than Group 3 (33.8 +/- 27.1% vs 4.7 +/- 4.6%, p= 0.000). There were no rP-gp (+) glomeruli in Group 2. The rate of mesangial proliferation was similar in Groups 1 and 2. There was no statistically significant correlation between rP-gp expression and total steroid dosage (r = 0.455, p = 0.160). Our findings showed that rP-gp expression is increased in patients receiving steroid therapy for NS regardless of the cumulative steroid dosage and mesangial cell proliferation.

a Topical term or geographic name as entry element Pediatrics

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Renal P-glycoprotein expression

a Main entry heading Nephrology Dialysis Transplantation

g Relationship information MAY-JUN 2013, Vol 55 Issue 3, p260-265

x International Standard Serial Number 00414301