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The protective effect of apelin against water-immersion and restraint stress-induced gastric damage (Izgut-Uysal, V. Nimet.)
Bibliographical information (record 264654)
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The protective effect of apelin against water-immersion and restraint stress-induced gastric damage
Author:
 Izgut-Uysal, V. Nimet. Search Author in Amazon Books

Publisher:
Tokyo
Edition:
 2014.
Classification:
 QT104
URL:
http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s12576-014-0317-8
Detailed notes
    - The aim of the present study was to investigate the gastroprotective effect of apelin on water-immersion and restraint stress (WIRS)-induced gastric lesions. Male Wistar rats were divided into four groups: control, WIRS, F13A + WIRS and F13A. APJ receptor antagonist F13A was administered to rats to determine the influence of apelin on stress-induced gastric injury. WIRS administered for 6 h resulted in the development of gastric mucosal lesions accompanied by a significant increase in plasma corticosterone. WIRS increased the concentration of 4-hydroxynonenol (4-HNE) + malondialdehyde (MDA) and the expression of apelin and hypoxia inducible factor-1 alpha (HIF-1 alpha) in gastric mucosa. In addition, WIRS reduced the mucosal blood flow and gastric prostaglandin E-2 (PGE(2)) concentration. Plasma corticosterone, which was increased due to stress, was significantly decreased in the F13A + WIRS group. Gastric lesions and the 4-HNE + MDA concentration were also higher in the F13A + WIRS compared to the WIRS group. We conclude that apelin has a gastroprotective effect against stress-induced lesions possibly by reducing lipid peroxidation in gastric mucosa.
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Section
EOL-159
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NEU Grand LibraryOnline (QT104 .P76 2014)
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